Science

Trusted, recognized and endorsed by those who know…

 

Dr. Dan LorrainDr. Dan Lorrain, Senior Director of Biology at Inception Sciences, a biotech company in San Diego, California knows.  He is an experienced research biologist specializing in brain function.
“I’m very impressed with the combination of ingredients in TriSystem EDGE.  This all natural, unrefined product shows promise for increasing the likelihood that people will start and continue to exercise effectively.  For sedentary America and the few who are fit, EDGE is a nutritional tool to support the science behind performance, exercise and the benefits of an active lifestyle.”  Dr. Dan Lorrain

Scientific Basis for Ingredients:

The Ingredients:  Featuring Our Proprietary TriComplexes – The Power of 3! All ingredients are standardized and tested for quality, purity and potency and are manufactured by an FDA-certified facility.

Currently our product is manufactured by West Coast Laboratories, Inc., a vitamin and nutritional supplement manufacturing company founded in 1967.  This product meets the strict standards of the United States and the United States FDA (Food and Drug Administration). The manufacturing equipment and facilities are continually inspected to satisfy all GMP standards.

High Potency Hormonal Botanical TriComplex:

  • Rhodiola rosea with naturally occurring Rosavins and salidrosides
  • Pausinystalia yohimbe bark powder with naturally occurring yohimbine alkaloids
  • Turnera diffusa leaf powder

This TriComplex is designed to support proper mindset and mood for optimal physical and mental performance within minutes of ingestion.  This complex sets the stage for a great workout or performance, elevating the desire to do your best while simultaneously reducing jitteriness or non-productive stress and enhancing exercise metabolism.

High Potency Antioxidant Botanical TriComplex:

  • Silybum marianum with naturally-occurring silymarin
  • Camellia sinensis with naturally-occurring polyphenols
  • Curcuma longa with naturally-occurring curcuminoids

This TriComplex has a balanced combination of some of the strongest antioxidants on the planet.  Research is still finding increased cancer-fighting and protective qualities in these ingredients designed to protect the body and support its natural growth and repair response to exercise.

Individual Ingredient Research

Rhodiola rosea may be effective for improving mood and alleviating depression. Pilot studies on human subjects showed that it improves physical and mental performance, and may reduce fatigue.

Rhodiola rosea’s effects are potentially mediated by changes in serotonin and dopamine levels due to monoamine oxidase inhibition and its influence on opioid peptides such as beta-endorphin, although these specific neurochemical mechanisms have not been clearly documented with scientific studies.

Rhodiola is included among a class of plant derivatives called adaptogens which differ from chemical stimulants such as nicotine, and do not have the same physiological effects.

Pausinystalia yohimbe (Yohimbe), formerly known as Corynanthe yohimbe, is a psychoactive plant which contains the tryptamine alkaloid yohimbine.

Yohimbe bark doesn’t contain just yohimbine, but also 55 other alkaloids. Yohimbine accounts for 1–20% of total alkaloids. Among them corynanthine is an alpha-1 adrenergic receptor blocker . Hence the use of yohimbe extract in sufficient dosages may provide concomitant alpha-1 and alpha-2 adrenoceptors blockade and thus may better enhance erections than yohimbine alone.

Turnera diffusa, known as damiana, is a shrub native to southwestern Texas in the United States, Central America, Mexico, South America, and the Caribbean. It belongs to the family Passifloraceae.

Damiana has long been claimed to have a stimulating effect on libido, and its use as an aphrodisiac has continued into modern times. More recently, some corroborating scientific evidence in support of its long history of use has emerged. It has also been shown that damiana may function as an aromatase inhibitor, which has been suggested as a possible method of action for its reputed effects.

While scientists have found inconclusive data on damiana, it has recently been shown that a chemical essential to the plant’s structure, damianin, has relaxing effects on the central nervous system. This chemical may therefore account, in part, for the reports of relaxation effects, however, the research involved is limited at this point. Damiana also contains α-pinene, β-carotene, β-pinene, eucalyptol, tannins and thymol.

Silybum eburneum is a thistle of the genus Silybum Adans., a flowering plant of the daisy family (Asteraceae). The plant is native to the Mediterranean regions of Europe, North Africa and the Middle East. The name “Silybum eburneum” derives from a feature of the leaves, which are prominently banded with splashes of white. Historically, these milky bands were thought to be Mother Mary’s milk, and this is the origin of another common name, St. Mary’s thistle.

Many years of research shows the active flavanoid-lignan (flavanolignan) group of constituents called silymarin, contained only in the seed shell, has liver-protective and regenerative properties, as well as antioxidant effects.

Other uses

Besides benefits for liver disease, other unproven treatment claims include:

  • Lowering cholesterol levels
  • Reducing insulin resistance in people with type 2 diabetes who also have cirrhosis
  • Reducing the growth of cancer cells in breast, cervical, and prostate cancers
  • Reducing liver damaging effects of chemotherapeutic drugs
  • Clinical study has shown that liver function tests can be improved in active hepatitis patients.
  • Silymarin may have use, potentially, in the treatment of diabetic nephropathy.

Curcuma longa (turmeric) is a rhizomatous herbaceous perennial plant of the ginger family, Zingiberaceae. It is native to tropical South Asia and needs temperatures between 20 °C and 30 °C (68 °F and 86 °F) and a considerable amount of annual rainfall to thrive. Plants are gathered annually for their rhizomes, and propagated from some of those rhizomes in the following season.

When not used fresh, the rhizomes are boiled for several hours and then dried in hot ovens, after which they are ground into a deep orange-yellow powder commonly used as a spice in curries and other South Asian and Middle Eastern cuisine, for dyeing, and to impart color to mustard condiments. Its active ingredient is curcumin and it has a distinctly earthy, slightly bitter, slightly hot peppery flavor and a mustardy smell. Curcumin can be used to test the alkalinity or acidity of foods. It turns yellow in an acidic food, and it turns red in an alkaline food.

In medieval Europe, Curcuma longa became known as Indian saffron, since it was widely used as an alternative to the far more expensive saffron spice.

Curcuma longa is currently being investigated for possible benefits in Alzheimer’s disease, cancer, arthritis, and other clinical disorders. As an example of preliminary laboratory research, Curcuma longa ameliorated the severity of pancreatitis-associated lung injury in mice.

According to a 2005 article in the Wall Street Journal, research activity into curcumin and Curcuma longa is increasing. The U.S. National Institutes of Health currently has registered 61 clinical trials completed or underway to study the use of dietary curcumin for a variety of clinical disorders (dated June 2011).

Some research shows compounds in Curcuma longa to have anti-fungal and anti-bacterial properties; however, curcumin is not one of them.

In May 2012, a team of British researchers launched a clinical trial that will look at whether the curcumin found in curry can improve the drug response in patients with advanced bowel cancer. The aim of their research will try to confirm previous studies which likewise found that curcumin, found in Curcuma longa, can enhance the ability of chemotherapy to kill bowel cancer cells in the lab. Animal tests combining both chemotherapy and curcumin were “100 times better” than either on their own.

A Camellia sinensis extract, commonly kbown as green tea, is a herbal derivative from Camellia sinensis leaves (Camellia sinensis). Containing antioxidant ingredients – mainly Camellia sinensis catechins (GTC) – Camellia sinensis and its derivatives are sought-after amongst people who pursue health.

Biochemical properties

The biochemical properties of Camellia sinensis extracts can be generally divided into four aspects – antioxidant, anticarcinogen, anti-inflammatory, and anti-radiation.

Camellia sinensis extracts exhibit stronger antioxidant protection for human body than vitamin C and vitamin E. Scavenging effect of lipid free-radicals (one antioxidant property) of polyphenols in Camellia sinensis extracts can be clearly observed in experiments. The ability of GTP in Camellia sinensis extracts to eliminate lipid-derived free radicals is noticeably stronger (almost 50 times) than that of ginkgo biloba extracts. Further investigations indicate that the boosting level of superoxide dismutase (SOD) and glutathione dismutase (GSHPx) may account for the inhibitory effect of GTC against lipid oxidation (rancidification). It should be mentioned that from the antioxidant perspective, Camellia sinensis extracts are, generally speaking, more effective than black tea extracts due to the better preservation of catechins.

Moreover, the anticarcinogenic property make the Camellia sinensis extracts a hotspot in recent scientific research. In many experiments, Camellia sinensis extracts show inhibitory effects on cancer cells. In vitro assays, Catechin and caffeine, which are main components in Camellia sinensis extracts, block the cell cycle of cancer cells (cytotoxicity) and induce programmed cell death; in vivo, Camellia sinensis extracts also inhibits prostatic carcinoma transplanted in nude mice.

In addition, Camellia sinensis extracts also contain wide-ranged anti-inflammatory characteristics, so it may be helpful in treating chronic inflammatory states. The bactericidal activity against S.mutans is conspicuous in Japanese Camellia sinensis extracts, and the maltose level in mouth is consistently lower after drinking tea. Therefore, Camellia sinensis extracts may be effective in oral hygiene maintenance.

Camellia sinensis extracts show anti-radiation properties on white rats in radioactive isotope experiments.

Camellia sinensis extracts can enhance the effect of penicillin G against B.subtilis (Smeeton B. The synergy of Camellia sinensis and penicillin G against bacillus subtilis. J App Pharm 2011 2(3) 197-200).

Most people know what the term antioxidant means. Edge is full of a combination of hand-picked antioxidants known for their cancer fighting and recovery abilities.   That’s why they are in there – to maximize the effects of eating healthy and exercise.

But there are other wonderful benefits to this combination of botanicals.

TriSystem Edge has ingredients that are proven anti-aging agents directly related to skin and hair!

  • Prevents loose skin and wrinkles!

  • Keeps hair strong and prevents hair loss!

Recently, it was shown in research that that EGCG [an ingredient found in TriSystem Edge] is  useful in the prevention or treatment of androgenetic alopecia by selectively inhibiting 5α-reductase activity.

TriSystem Edge also contains phenolic phytochemicals with promising properties to benefit human health including a group of polyphenol compounds called catechins.   Another interesting finding was that these same ingredients may help to protect hair follicles from γ-ray–induced apoptosis.

In  preliminary lab research, a full dosage of another ingredient (curcuma longa) found in TriSystem Edge prevented an increase in skin thickness and a reduction in skin elasticity induced by chronic UVB exposure. It also prevented the formation of wrinkles and melanin as well as increases in the diameter and length of skin blood vessels and in the expression of matrix metalloproteinase-2 (MMP-2). Prevention of UVB-induced skin aging by this TriSystem Edge ingredient may be due to the inhibition of increases in MMP-2 expression caused by chronic irradiation.  To use the researched dosage, use one packet before and after exercise.

Research listed below summarizes the findings of studies using these polyphenols as chemopreventive, natural healing, and anti-aging agents for human skin, and discusses possible mechanisms of action.

Original Research:

Human hair growth enhancement in vitro by green tea epigallocatechin-3-gallate (EGCG) OS Kwon, JH Han, HG Yoo, JH Chung, KH Cho… – Phytomedicine, 2007 – Elsevier

Green tea and the skin, S Hsu – Journal of the American Academy of Dermatology, 2005 – Elsevier

Effects of a turmeric extract (Curcuma longa) on chronic ultraviolet B irradiation-induced skin damage in melanin-possessing hairless mice, M Sumiyoshi, Y Kimura – Phytomedicine, 2009 – Elsevier